Drug-Induced TdP Risk Assessment
Dataset:4834866
DOI10.5281/ZENODO.8058964Zenodo8058964MaRDI QIDQ4834866
Dataset in the Graphical Modelling and Causal Inference Zenodo Community
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Publication date: 27 July 2020
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Community: Graphical Modelling and Causal Inference
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020).
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