Single-cell repertoire and transcriptome sequencing reveals clonally expanded and transcriptionally distinct lymphocytes in aged CNS

DOI10.5281/zenodo.4264462Zenodo4264462MaRDI QIDQ6680325

Dataset published at Zenodo repository.

Alexander Yermanos

Publication date: 9 November 2020

Copyright license: Creative Commons Attribution 4.0 International

Description

Single-cell repertoire and transcriptome sequencing reveals clonally expanded and transcriptionally distinct lymphocytes in aged CNS. Gene expression and immune receptor repertoire sequencing was performing for both B and T cells. This dataset contains the VDJ sequencing information for the four samples. Each B cell and T cell library was sequenced across four lanes. Files with _WT_ in their name correspond to the young (4-6 week B6 mice) Files with _12_ in their name before the BDJ or VDJ text correspond to the 12-month-old cohort. Files with _18_in their name before the BDJ or VDJ text correspond to the 18-month-old cohort in which four brains were pooled. Files with 4_18_in their name before the BDJ or VDJ text correspond to the 18-month-old mouse that was processed and sequenced alone. The L001 - L004 in the file names indicates the sequencing lane. Samples with BDJ correspond to the B cell repertoire library (B cell VDJ). Samples with TDJ correspond to the T cell repertoire library (T cell VDJ).

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