Glucose transport in a model of the rat proximal tubule epithelium (Q1060148)

A mathematical model of the rat proximal tubule epithelium has been extended to include terms for glucose-sodium cotransport, as well as the passive permeability properties of urea. Except for a metabolically driven \(Na^+-K^+\) exchanger at the cell basolateral membrane, all membrane transport is represented by the relations of linear nonequilibrium thermodynamics. Use of this formalism permits the explicit calculation of the intracellular depolarization immediately following the luminal application of glucose, and shows the magnitude of this potential deflection proportional to the glucose chemical-potential change.