A regularization procedure for estimating cell kinetic parameters from flow-cytometry data (Q1080794)
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scientific article; zbMATH DE number 3968407
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | A regularization procedure for estimating cell kinetic parameters from flow-cytometry data |
scientific article; zbMATH DE number 3968407 |
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A regularization procedure for estimating cell kinetic parameters from flow-cytometry data (English)
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1986
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The problem of estimating kinetic parameters such as the DNA synthesis rate and the S-phase influx in a cell population monitored by flow cytometry is considered. The population can be in any growth state, assuming that there is no cell loss. The growth curve of the population and a sequence of DNA-content histograms are required data. Our approach, based on the use of continuity equations to model the population dynamics, utilizes a regularization procedure in order to filter the population-size data. Some properties of the procedure, together with an evaluation of its performance on simulated data, are presented.
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biochemistry
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estimating kinetic parameters
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DNA synthesis rate
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S-phase influx
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cell population
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flow cytometry
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growth curve
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DNA-content histograms
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continuity equations
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regularization procedure
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