Robust design in a two treatment comparison in the presence of a covariate (Q1095552)
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scientific article; zbMATH DE number 4028697
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Robust design in a two treatment comparison in the presence of a covariate |
scientific article; zbMATH DE number 4028697 |
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Robust design in a two treatment comparison in the presence of a covariate (English)
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1987
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In clinical trials the response of a subject to one of two treatments may depend upon a covariate. Estimates of the difference in the expected responses as a function of the covariate with minimum mean squared error depend upon the model used and the allocation of the treatments to subjects. For nearly linear models, minimax estimates are obtained and an optimum allocation procedure is described.
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comparison of two treatments
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robust design
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clinical trials
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expected responses
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covariate
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minimum mean squared error
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nearly linear models
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minimax estimates
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optimum allocation procedure
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