The singularly perturbed Hodgkin-Huxley equations as a tool for the analysis of repetitive nerve activity (Q1117855)

A qualitative analysis of the Hodgkin-Huxley model, which closely mimics the ionic processes at a real nerve membrane, is performed by means of a singular perturbation theory. This is achieved by introducing a perturbation parameter that, if decreased, ``speeds up'' the fast variables of the Hodgkin-Huxley equations (membrane potential and sodium activation), whereas it does not affect the slow variables (sodium inactivation and potassium activation). In the most extreme case, if the perturbation parameter is set to zero, the original four-dimensional system ``degenerates'' to a system with only two differential equations. This degenerate system is easier to analyze and much more intuitive than the original Hodgkin-Huxley equations. It shows, like the original model, an infinite train of action potentials if stimulated by an input current in a suitable range. Additionally, explanations for the increased sensitivity to depolarizing current steps that precedes an action potential can be found by analysis of the degenerate system. Using singular perturbation theory it is shown that the degenerate system does not only represent a simplification of the original Hodgkin-Huxley equations but also gives a valid approximation of the original model at least for stimulating currents that are constant within a suitable range.