Nonparametric equivalents of contrasts for identifying the minimum effective dose (Q1775978)
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scientific article; zbMATH DE number 2169421
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Nonparametric equivalents of contrasts for identifying the minimum effective dose |
scientific article; zbMATH DE number 2169421 |
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Nonparametric equivalents of contrasts for identifying the minimum effective dose (English)
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20 May 2005
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The author considers Mann-Whitney versions of the families of contrasts (namely, pairwise, Helmert and step contrasts) and proposes two new nonparametric step-down procedures for identifying the minimum effective dose (MED) in a one-way layout with general dose-response relationship. The step-down testing scheme for determining the MED is described, critical and adjusted \(p\)-values of identified MED are obtained. Results of Monte-Carlo simulation studies directed on comparison of the relative error rate and power performance for various nonparametric step-down tests are presented and discussed.
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dose-response study
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Helmert contrasts
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nonparametric test
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pairwise contrasts
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step contrasts
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step-down test
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Mann-Whitney statistics
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