Conceptual models of respiratory system control and their analysis by mathematical modeling (Q1842422)

Modeling the process of control (or self-regulation) of the respiratory system in the organism of man and animals is one of the most important tasks in physiology of respiration. The construction of a model and its analysis are actually linked with understanding the nature of the mechanisms, including physiological mechanisms, that satisfy the needs of the living organism for biological energy. Modern science provides a considerable number of models, both conceptual and mathematical, that represent in one form or another the existing knowledge about the process of self-regulation of the respiratory system. The form of the models is usually determined by the modeling goals and the degree of completeness of the description of the modeled object. Conceptual models in modern respiratory physiology are based on an analysis of rich experimental material and incorporate methods of automatic control theory in the description of the schema. The mathematical models are based on specific conceptual models, and a mathematical model in fact provides a formal expression of the underlying conceptual model. Unfortunately, the accepted division in human physiology into physiology of external respiration and tissue respiration has led to the emergence of separate mathematical models, which is an obstacle to a system analysis of regulation of the main respiratory function in the entire organism. The present article considers systemic regulation mechanisms of the entire organism that support the main function of the respiratory system.