An optimal control strategy for antiretroviral treatment of HIV infection in presence of immunotherapy (Q2114395)
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scientific article; zbMATH DE number 7489695
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | An optimal control strategy for antiretroviral treatment of HIV infection in presence of immunotherapy |
scientific article; zbMATH DE number 7489695 |
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An optimal control strategy for antiretroviral treatment of HIV infection in presence of immunotherapy (English)
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15 March 2022
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This paper proposes and presents a stability analysis of an HIV infection model incorporating the effects of antiretroviral drugs and immunotherapy. The authors study an optimal control problem to maximize healthy CD4+ T cells with minimum cost and side effects of drugs. By using discretization and large-scale optimization methods, they obtain optimal treatment strategies for antiretroviral drugs and immune boosting drugs.
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optimal control
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HIV infection
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Pontryagin's maximum principle
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immunotherapy
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antiretroviral drugs
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