Synthetic mutational spectra with mixed and correlated mutational signatures SBS1 and SBS5 (Q6686430)

Experience suggeststhat it harder to extract mutational signatures that always co-occur and that generate correlated numbers of mutations. Here we provide12 data sets, each consisting of 500 synthetic mutational spectrawith varying degrees of mixture and correlation between two mutational signatures. The signatures studied were SBS1, a clock-like signature due to deamination of 5-methyl cytosine that consists primarily of mutations from CGTG, and SBS5, a relatively flat clock-like signature. By clock-like we mean that the numbers of mutations attributable to these signatures increase with patients ages. The 12 data sets varied intwo dimensions: (i) average ratio of the number of SBS1 to the number of SBS5 mutations in spectra in the data set and (ii) correlation between the number of SBS1 and the number of SBS5 mutations in spectrain the data set. The mutational signatures SBS1 and SBS5 are described at https://doi.org/10.7303/syn12025148andhttps://doi.org/10.1101/322859.