Comparison of isoeffect relationships in radiotherapy (Q917479)

In the radiotherapy of tumors, the choice of the fractionation regimen of dose over time is as crucial as the total radiation dose. The interdependence between total dose fractionation regimen, and radiation effect has been described mathematically with various isoeffect relationships. These relationships appear to be fundamentally distinct and have been considered unrelated; some even claim that one class of isoeffect relationships is appropriate whereas other relationships are rather useless. We examine how alternative isoeffect models relate to each other and test the reliability of estimating parameter values of one model from the other.