A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with toll-like receptor 4 demonstrates inherent preconditioning behavior

DOI10.1016/j.mbs.2008.10.002zbMath1158.92027OpenAlexW1985503444WikidataQ37118455 ScholiaQ37118455MaRDI QIDQ1013277

David Swigon, Yoram Vodovotz, Yekaterina Epshteyn, Béatrice Rivière

Publication date: 17 April 2009

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2651675

zbMATH Keywords

tolerancepreconditioningmathematical modelinflammationsepsisendotoxin

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Dynamical systems in biology (37N25) Medical applications (general) (92C50)

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A low dimensional dynamical model of the initial pulmonary innate response to infection ⋮ Mathematical models for immunology: current state of the art and future research directions ⋮ A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia ⋮ Mechanistic simulations of inflammation: current state and future prospects

Cites Work

• A reduced mathematical model of the acute inflammatory response. II: Capturing scenarios of repeated endotoxin administration