Modelling the activation of G-protein coupled receptors by a single drug

DOI10.1016/J.MBS.2009.02.003zbMath1187.92043OpenAlexW2003905559WikidataQ51794624 ScholiaQ51794624MaRDI QIDQ1025228

S. J. Hill, P. J. Woodroffe, John R. King, Lloyd J. Bridge

Publication date: 18 June 2009

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2009.02.003

zbMATH Keywords

asymptotic analysiscell signallingG-protein coupled receptor

Mathematics Subject Classification ID

Biomedical imaging and signal processing (92C55) Dynamical systems in biology (37N25) Biochemistry, molecular biology (92C40) Physiology (general) (92C30) Cell biology (92C37) Asymptotic theory for ordinary differential equations (34E99)

Related Items (6)

Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition ⋮ Kinetic operational models of agonism for G-protein-coupled receptors ⋮ Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor ⋮ Insights into the dynamics of ligand-induced dimerisation via mathematical modelling and analysis ⋮ Ligand binding dynamics for pre-dimerised G protein-coupled receptor homodimers: linear models and analytical solutions ⋮ Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity

Cites Work

• Metabotropic receptor activation, desensitization and sequestration. I: Modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
• Asymptotic analysis of the steady-state and time-dependent Berman problem

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