Penalized optimal designs for dose-finding

DOI10.1016/j.jspi.2009.07.012zbMath1177.62093OpenAlexW2079952726MaRDI QIDQ1036729

Luc Pronzato

Publication date: 13 November 2009

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2009.07.012

zbMATH Keywords

constrained optimal designsbivariate binary modelcompound optimal designspenalized experimental designs

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05) Parametric inference under constraints (62F30) Sequential statistical design (62L05)

Related Items (8)

Evaluation of the Fisher information matrix in nonlinear mixed effect models using adaptive Gaussian quadrature ⋮ Optimal designs for contingent response models with application to toxicity-efficacy studies ⋮ A Bayesian adaptive dose-finding algorithm for balancing individual- and population-level ethics in Phase I clinical trials ⋮ Optimal designs subject to cost constraints in simultaneous equations models ⋮ Incorporating Individual and Collective Ethics into Phase I Cancer Trial Designs ⋮ Barycentric algorithm for computing D-optimal size- and cost-constrained designs of experiments ⋮ On optimal designs for clinical trials: an updated review ⋮ Asymptotic properties of nonlinear estimates in stochastic models with finite design space

Cites Work

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• Improvements on removing nonoptimal support points in \(D\)-optimum design algorithms
• Properties of frequency distributions induced by general up-and-down methods for estimating quantiles
• Model-oriented design of experiments
• Adaptive optimization and \(D\)-optimum experimental design.
• One-step ahead adaptive \(D\)-optimal design on a finite design space is asymptotically optimal
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Adaptive designs for dose-finding based on efficacy-toxicity response
• Bayesian Optimal Designs for Phase I Clinical Trials
• The Equivalence of Two Extremum Problems
• A New Dose‐Finding Design for Bivariate Outcomes
• On the Equivalence of Constrained and Compound Optimal Designs
• Adaptive control for sequential design
• Invited Discussion Paper Constrained Optimization of Experimental Design
• Optimizing a Unimodal Response Function for Binary Variables
• An Optimizing Up-and-Down Design
• Nonlinear Experiments: Optimal Design and Inference Based on Likelihood

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