Reduction of cytotoxicity to normal tissues by new regimens of cell-cycle phase-specific drugs

DOI10.1016/0025-5564(88)90002-8zbMath0655.92004OpenAlexW2090180109MaRDI QIDQ1109704

B. Schechter, R. Arnon, Zvia Agur

Publication date: 1988

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(88)90002-8

zbMATH Keywords

chemotherapycell-cycle lengthcell-cycle phase-specific drugscytosine arabinosideleukemic cell lineminimizing cytotoxicity to normal tissuesperiod of drug applicationshort drug pulses

Mathematics Subject Classification ID

Medical applications (general) (92C50) Physiological, cellular and medical topics (92Cxx)

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Cites Work

• The effect of environmental disturbances on the dynamics of marine intertidal populations
• Mathematical model of cancer chemotherapy. Periodic schedules of phase- specific cytotoxic-agent administration increasing the selectivity of therapy
• Estimation and prediction of cell cycle specific effects of anticancer drugs