Time-dependent subpopulation induction in heterogeneous tumors

DOI10.1007/BF02460096zbMath0656.92005OpenAlexW2037464275WikidataQ52579469 ScholiaQ52579469MaRDI QIDQ1110467

Seth Michelson, John T. Leith, István Győri

Publication date: 1988

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/bf02460096

zbMATH Keywords

tumor microenvironmentmutation ratecytotoxicitycytotoxic agentAsymptotic closed form solutionsdrug resistance in tumorsdrug resistant subclonesemergence rate functionsgrowing neoplasmJRE Modelneoplastic micro-environmentTime-dependent induction of clonal heterogeneity

Mathematics Subject Classification ID

Medical applications (general) (92C50) Ecology (92D40) Physiological, cellular and medical topics (92Cxx)

Related Items

A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment, A mathematical model of drug resistance: Heterogeneous tumors, Nonautonomous Dynamical Systems in the Life Sciences, Nonlinear mathematical model of pulsed-therapy of heterogeneous tumors

Cites Work

• The effect of cellular differentiation on the development of permanent drug resistance
• A branching-process model for heterogeneous cell populations
• Analysis of the growth of tumor cell populations