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Mathematical properties of compartment models with MichaelisMenten type elimination

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Publication:1138514
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DOI10.1016/0025-5564(80)90063-2zbMath0431.92015OpenAlexW2074720751MaRDI QIDQ1138514

C. M. Metzler, Donald D. M. Tong

Publication date: 1980

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(80)90063-2

zbMATH Keywords

boundscomparison theoremsenzyme kineticscompartment modelspseudo-steady-state hypothesisill-conditioning of estimation of parameters of differential equationMichaelis-Menten type elimination


Mathematics Subject Classification ID

Nonlinear ordinary differential equations and systems (34A34) Medical applications (general) (92C50) Chemical kinetics in thermodynamics and heat transfer (80A30) Physiological, cellular and medical topics (92Cxx)


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Direct and indirect least squares methods in continuous-time parameter estimation, Procedures for parameter and state estimation of microbial growth process models, On the practical identifiability of microbial growth models incorporating Michaelis-Menten type nonlinearities, Factors affecting the identifiability of compartmental models



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