On the kinectics and optimal specificity of cytotoxic reactions mediated by T-lymphocyte clones

DOI10.1007/BF02459933zbMath0747.92017WikidataQ51148789 ScholiaQ51148789MaRDI QIDQ1194433

Jacques Urbain, René Lefever, Patricia Meyers, Jacques Hiernaux

Publication date: 27 September 1992

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

zbMATH Keywords

immune responsetumour progression\(T\) lymphocyte cytotoxic activityagarosecancer cell replicationchromium release assayeffector-target conjugationeffector-target ratiolethal hit deliveryMHC-restricted \(T\) lymphocyte clonesnon-Michaelian behaviourP1:3P89:15single celle assaysyngeneic P815 mastocytoma cellstumour antigenstumour regression

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Related Items (8)

ROLE OF CYTOTOXIC T-LYMPHOCYTES IN TUMOR STABILITY: A PREY-PREDATOR MODELING APPROACH ⋮ From population dynamics to modelling the competition between tumors and immune system ⋮ Oscillations and bistability in the dynamics of cytotoxic reactions mediated by the response of immune cells to solid tumours ⋮ Temporal and spatiotemporal variations in a mathematical model of macrophage-tumor inter\-action ⋮ A mathematical model of the effector cell response to cancer ⋮ A Feedback Control Model of Comprehensive Therapy for Treating Immunogenic Tumours ⋮ Spatiotemporal dynamics of immunogenic tumors ⋮ Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis

Cites Work

• Approximate Michaelis-Menten kinetics displayed in a stochastic model of cell-mediated cytotoxicity
• On the validity of the steady state assumption of enzyme kinetics
• Foundations of the use of an enzyme-kinetic analogy in cell-mediated cytotoxicity

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