A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events

DOI10.1016/S0025-5564(97)10007-4zbMath0953.92020OpenAlexW1993148131WikidataQ52242444 ScholiaQ52242444MaRDI QIDQ1306986

P. Bannasch, Annette Kopp-Schneider, Christopher J. Portier

Publication date: 29 January 2001

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/s0025-5564(97)10007-4

zbMATH Keywords

likelihoodbirth and death processmultistage modelfocal liver lesionstochastic carcinogenesis model

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of branching processes (60J85) Medical applications (general) (92C50) Cell biology (92C37) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80)

Related Items (5)

Application of a two-phenotype color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment ⋮ Using a stochastic model to analyze the sequence of phenotypic changes in rat liver focal lesions ⋮ Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment ⋮ A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells ⋮ Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions

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• The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments
• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• Birth-death processes with piecewise constant rates
• A stem cell model for carcinogenesis
• Birth-and-death processes, and the theory of carcinogenesis

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