A mathematical model for the inhibition of the multidrug resistance- associated \(p\)-glycoprotein pump

DOI10.1007/BF02460640zbMath0789.92020OpenAlexW4234548383WikidataQ52381008 ScholiaQ52381008MaRDI QIDQ1319883

Seth Michelson, Doris Slate

Publication date: 14 June 1994

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/bf02460640

zbMATH Keywords

simulationsresponse surfaceanti-cancer drugbinding requirementscytoplasmic exposuredrug therapiesenergy-dependent model of facilitated diffusionmultidrug resistance inhibitorsp170 glycoprotein pumpultimate tumor cell survival

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites Work

• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• The effect of cellular differentiation on the development of permanent drug resistance
• A branching-process model for heterogeneous cell populations
• A mathematical model of the P-glycoprotein pump as a mediator of multidrug resistance

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