Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

DOI10.48550/arXiv.1801.09652zbMath1465.62050arXiv1801.09652OpenAlexW3042936392MaRDI QIDQ151893

Dylan S. Small, Jingshu Wang, Qingyuan Zhao, Gibran Hemani, Jack Bowden, Jingshu Wang, Jack Bowden, Dylan S. Small, Gibran Hemani, Qingyuan Zhao

Publication date: 29 January 2018

Published in: The Annals of Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1801.09652

zbMATH Keywords

errors in variablesweak instrumentscausal inferencepath analysislimited information maximum likelihoodpleiotropy effects

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Parametric hypothesis testing (62F03) Robustness and adaptive procedures (parametric inference) (62F35) Applications of functional analysis in biology and other sciences (46N60) General theory of numerical analysis in abstract spaces (65J05)

Related Items (13)

On Semiparametric Instrumental Variable Estimation of Average Treatment Effects through Data Fusion ⋮ Hypothesis Testing in High-Dimensional Instrumental Variables Regression With an Application to Genomics Data ⋮ Breaking the winner's curse in Mendelian randomization: rerandomized inverse variance weighted estimator ⋮ Two robust tools for inference about causal effects with invalid instruments ⋮ Weak‐instrument robust tests in two‐sample summary‐data Mendelian randomization ⋮ Mendelian Randomization Test of Causal Effect Using High-Dimensional Summary Data ⋮ Causal Inference in Transcriptome-Wide Association Studies with Invalid Instruments and GWAS Summary Data ⋮ A Novel Penalized Inverse-Variance Weighted Estimator for Mendelian Randomization with Applications to COVID-19 Outcomes ⋮ Mendelian Randomization Mixed-Scale Treatment Effect Robust Identification and Estimation for Causal Inference ⋮ Wilcoxon-Mann-Whitney statistics in randomized trials with non-compliance ⋮ mr.raps ⋮ Debiased inverse-variance weighted estimator in two-sample summary-data Mendelian randomization ⋮ Two-sample instrumental variable analyses using heterogeneous samples

Uses Software

• PLINK
• robustbase

Cites Work

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• Confidence Intervals for Causal Effects with Invalid Instruments using Two-Stage Hard Thresholding with Voting
• High breakdown-point and high efficiency robust estimates for regression
• Robust inference for the two-sample 2SLS estimator
• Likelihood inference in the errors-in-variables model
• On a formula for the distribution of the maximum likelihood estimator
• The Influence Curve and Its Role in Robust Estimation
• Alternative Approximations to the Distributions of Instrumental Variable Estimators
• Mendelian randomization as an instrumental variable approach to causal inference
• Robust Statistics
• Measurement Error in Nonlinear Models
• Robust Estimation of a Location Parameter
• Identification in Parametric Models
• Estimation of the Parameters of a Single Equation in a Complete System of Stochastic Equations
• Consistent Estimates Based on Partially Consistent Observations

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