A score test for linkage using identity by descent data from sibships

DOI10.1214/aos/1018031264zbMath0957.62101OpenAlexW2044382573MaRDI QIDQ1568307

Sandrine Dudoit, Terence P. Speed

Publication date: 29 March 2001

Published in: The Annals of Statistics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1214/aos/1018031264

zbMATH Keywords

orbitseigenvaluesMarkov chainscore testadjacency matrixinfinitesimal generatorlinkage analysisquotient graphPolya's theory

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Parametric hypothesis testing (62F03) Applications of graph theory (05C90) Enumeration in graph theory (05C30) Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Eigenvalues, singular values, and eigenvectors (15A18) Genetics and epigenetics (92D10)

Related Items (7)

Spectral decomposition of score functions in linkage analysis ⋮ Modeling the effect of inbreeding among founders in linkage analysis ⋮ Asymptotic estimation theory of multipoint linkage analysis under perfect marker information. ⋮ Genetic linkage methods for quantitative traits ⋮ Allele-sharing among affected relatives: non-parametric methods for identifying genes ⋮ Score Tests for Exploring Complex Models: Application to HIV Dynamics Models ⋮ A score test for linkage using identity by descent data from sibships

Cites Work

• The probability that related individuals share some section of genome identical by descent
• A score test for linkage using identity by descent data from sibships
• A Class of Tests for Linkage Using Affected Pedigree Members
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