A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells

DOI10.1016/S0025-5564(00)00044-4zbMath0971.92017OpenAlexW2134973471WikidataQ52070004 ScholiaQ52070004MaRDI QIDQ1595410

Iris Geisler, Annette Kopp-Schneider

Publication date: 30 October 2001

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/s0025-5564(00)00044-4

zbMATH Keywords

stereologyclonal expansionmulti-stage modelhepatocarcinogenesis

Mathematics Subject Classification ID

Applications of branching processes (60J85) Medical applications (general) (92C50)

Related Items (2)

Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment ⋮ Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions

Cites Work

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• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
• Two-mutation model for carcinogenesis: Joint analysis of premalignant and malignant lesions
• Birth-and-death processes, and the theory of carcinogenesis

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