Why are cellular switches Boolean? General conditions for multistable genetic circuits

DOI10.1016/j.jtbi.2009.07.019zbMath1403.92075OpenAlexW2014896276WikidataQ62085704 ScholiaQ62085704MaRDI QIDQ1628826

Stefanie Widder, Javier Macía, Ricard V. Solé

Publication date: 11 December 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2009.07.019

zbMATH Keywords

multistabilitytristabilityminimal genetic circuitnullclines analysis

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37) Systems biology, networks (92C42)

Related Items (4)

Denoising of genetic switches based on Parrondo's paradox ⋮ Random discrete competing events vs. dynamic bistable switches in cell proliferation in differentiation ⋮ Equilibrium switching and mathematical properties of nonlinear interaction networks with concurrent antagonism and self-stimulation ⋮ Monostability and bistability of biological switches

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• A topological theorem for nonlinear dynamics in chemical and ecological networks
• Multistability in Spiking Neuron Models of Delayed Recurrent Inhibitory Loops
• Common pattern formation, modularity and phase transitions in a gene network model of morphogenesis

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