A computational model integrating brain electrophysiology and metabolism highlights the key role of extracellular potassium and oxygen

DOI10.1016/J.JTBI.2018.02.029zbMath1397.92276OpenAlexW2789492653WikidataQ52659805 ScholiaQ52659805MaRDI QIDQ1642502

G. Capo Rangel, Erkki Somersalo, Daniela Calvetti, Luca Gerardo-Giorda

Publication date: 15 June 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://hdl.handle.net/20.500.11824/829

zbMATH Keywords

brain signaling activitycompartment metabolic modelneuronal membrane potential

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Related Items (5)

Modeling the effect of cerebral capillary blood flow on neuronal firing ⋮ A spatially distributed model of brain metabolism highlights the role of diffusion in brain energy metabolism ⋮ Estimating hemodynamic stimulus and blood vessel compliance from cerebral blood flow data ⋮ Metabolism plays a central role in the cortical spreading depression: evidence from a mathematical model ⋮ Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: evidence from an integrated computational model

Cites Work

• A spatially distributed computational model of brain cellular metabolism
• Uncertainty quantification in flux balance analysis of spatially lumped and distributed models of neuron-astrocyte metabolism
• Mathematical physiology. II: Systems physiology
• A reaction-diffusion model of CO\(_2\) influx into an oocyte
• Dynamic activation model for a glutamatergic neurovascular unit

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