Transient alleviation of tumor hypoxia during first days of antiangiogenic therapy as a result of therapy-induced alterations in nutrient supply and tumor metabolism -- analysis by mathematical modeling

DOI10.1016/J.JTBI.2018.04.035zbMath1397.92340OpenAlexW2800409900WikidataQ88503717 ScholiaQ88503717MaRDI QIDQ1642627

Andrey V. Kolobov, Maxim B. Kuznetsov

Publication date: 15 June 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.04.035

zbMATH Keywords

Warburg effectbevacizumabnormalization windowtumor oxygenation

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Related Items (5)

Analysis of anticancer efficiency of combined fractionated radiotherapy and antiangiogenic therapy via mathematical modelling ⋮ Mathematical modelling for spatial optimization of irradiation during proton radiotherapy with nanosensitizers ⋮ A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment ⋮ Investigation of solid tumor progression with account of proliferation/migration dichotomy via Darwinian mathematical model ⋮ Optimization of antitumor radiotherapy fractionation via mathematical modeling with account of 4 R's of radiobiology

Uses Software

• SHASTA

Cites Work

• Unnamed Item
• Modeling the inhibition of breast cancer growth by GM-CSF
• A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology
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• New insights into vascular collapse and growth dynamics in solid tumors
• How tumour-induced vascular changes alter angiogenesis: insights from a computational model
• The Role of Cell Motility in Metastatic Cell Dominance Phenomenon: Analysis by a Mathematical Model
• Flux-corrected transport. I: SHASTA, a fluid transport algorithm that works

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