Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor

DOI10.1016/J.JTBI.2018.01.010zbMath1397.92274OpenAlexW2784055936WikidataQ47562869 ScholiaQ47562869MaRDI QIDQ1649408

Y. Aharonov

Publication date: 6 July 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.01.010

zbMATH Keywords

ordinary differential equationsreceptor theorybiased signallingG protein-coupled receptorsmathematical pharmacology

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Uses Software

• PottersWheel
• Unnamed Item

Cites Work

• Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy
• Modulation of the camp response by \(\mathrm{G}\alpha _i\) and \(\mathrm{G}\beta \gamma \): a computational study of G protein signaling in immune cells
• Modelling the activation of G-protein coupled receptors by a single drug
• Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity
• Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: agonist-antagonist competition

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