Mathematical modeling of antibody drug conjugates with the target and tubulin dynamics to predict AUC

DOI10.1016/J.JTBI.2018.01.028zbMath1397.92275OpenAlexW2792992934WikidataQ50153374 ScholiaQ50153374MaRDI QIDQ1649441

Jong Hyuk Byun, Il Hyo Jung

Publication date: 6 July 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.01.028

zbMATH Keywords

half-lifearea under the curve (AUC)monoclonal antibodies (mAbs)pharmacokinetics and pharmacodynamics (PKPD)target mediated drug disposition (TMDD)

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Global stability of solutions to ordinary differential equations (34D23)

Related Items (1)

Mathematical modeling of the receptor-mediated endocytosis process of targeted therapeutic agents in drug delivery systems

Cites Work

• Dynamics of target-mediated drug disposition: how a drug reaches its target
• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• A mathematical analysis of rebound in a target-mediated drug disposition model. I: Without feedback

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