Pharmacokinetically guided optimum adaptive dose selection in early phase clinical trials

DOI10.1016/j.csda.2017.02.009zbMath1464.62016OpenAlexW2590308184MaRDI QIDQ1654244

Barbara Bogacka, D. Stephen Coad, M. Iftakhar Alam

Publication date: 7 August 2018

Published in: Computational Statistics and Data Analysis (Search for Journal in Brave)

Full work available at URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/22491

zbMATH Keywords

continuation ratio modelpopulation pharmacokinetics\(D\)-optimum sampling timesarea under the concentration curveone-compartment pharmacokinetic model

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Uses Software

• S-PLUS
• MEMSS
• Cubature

Cites Work

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