A Bayesian adaptive design for clinical trials in rare diseases

DOI10.1016/j.csda.2016.09.006zbMath1464.62183OpenAlexW2526051401WikidataQ38718256 ScholiaQ38718256MaRDI QIDQ1658148

Thomas Jaki, Sofía S. Villar, S. Faye Williamson, Peter Jacko

Publication date: 14 August 2018

Published in: Computational Statistics and Data Analysis (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.csda.2016.09.006

zbMATH Keywords

dynamic programmingclinical trialssequential allocationbandit modelsBayesian adaptive designsrare diseases

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Related Items (10)

Response adaptive designs for phase II trials with binary endpoint based on context-dependent information measures ⋮ Generalisations of a Bayesian decision-theoretic randomisation procedure and the impact of delayed responses ⋮ Advances in medical statistics ⋮ A comparison of allocation strategies for optimising clinical trial designs under variance heterogeneity ⋮ Nonmyopic and pseudo-nonmyopic approaches to optimal sequential design in the presence of covariates ⋮ A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule ⋮ Rejoinder: response-adaptive randomization in clinical trials ⋮ Response-adaptive randomization in clinical trials: from myths to practical considerations ⋮ Using biomarkers to allocate patients in a response-adaptive clinical trial ⋮ Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule

Cites Work

• Unnamed Item
• Unnamed Item
• Unnamed Item
• Multi-armed bandit models for the optimal design of clinical trials: benefits and challenges
• Response‐adaptive randomization for multi‐arm clinical trials using the forward looking Gittins index rule
• Design for the Control of Selection Bias
• Resolving the conflict over fisher's exact test
• The Randomized Play-the-Winner Rule in Medical Trials
• Contingency Table Analysis
• Design and Analysis of Clinical Trials
• Optimal adaptive randomized designs for clinical trials
• The Theory of Response‐Adaptive Randomization in Clinical Trials

This page was built for publication: A Bayesian adaptive design for clinical trials in rare diseases