High cooperativity in negative feedback can amplify noisy gene expression

DOI10.1007/s11538-018-0438-yzbMath1396.92022OpenAlexW2612955377MaRDI QIDQ1670463

Abhyudai Singh, Pavol Bokes, Yen Ting Lin

Publication date: 5 September 2018

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1101/125914

zbMATH Keywords

asymptotic expansionsnegative feedbackstochastic gene expressiondelayed productionprotein bursting

Mathematics Subject Classification ID

Other physical applications of random processes (60K40) Biochemistry, molecular biology (92C40)

Related Items (5)

Exact and WKB-approximate distributions in a gene expression model with feedback in burst frequency, burst size, and protein stability ⋮ Analytic solutions for stochastic hybrid models of gene regulatory networks ⋮ Exponential equilibration of genetic circuits using entropy methods ⋮ Mixture distributions in a stochastic gene expression model with delayed feedback: a WKB approximation approach ⋮ Heavy-tailed distributions in a stochastic gene autoregulation model

Uses Software

• StochPy

Cites Work

• Protein synthesis driven by dynamical stochastic transcription
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• Stochastic modeling and numerical simulation of gene regulatory networks with protein bursting
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• Rare events in stochastic populations under bursty reproduction
• Bistable switching asymptotics for the self regulating gene
• Characteristics of mRNA dynamics in a multi-on model of stochastic transcription with regulation
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