Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine

DOI10.3934/NACO.2018004zbMath1406.92318OpenAlexW2793129344MaRDI QIDQ1713207

Anna Marciniak-Czochra, Z. Afsharnezhad, Reihaneh Mostolizadeh

Publication date: 24 January 2019

Published in: Numerical Algebra, Control and Optimization (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/naco.2018004

zbMATH Keywords

singularityPontryagin's maximum principleacute lymphoblastic leukemia (ALL)chimeric antigen receptor (CAR)T cellcytokine release syndrome

Mathematics Subject Classification ID

Applications of optimal control and differential games (49N90) Medical applications (general) (92C50)

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Study of dose-dependent combination immunotherapy using engineered T cells and IL-2 in cervical cancer ⋮ CAR T cells for T-cell leukemias: insights from mathematical models ⋮ On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: insights from a mathematical model ⋮ Understanding the interplay of CAR-NK cells and triple-negative breast cancer: insights from computational modeling ⋮ An optimal treatment strategy for a leukemia immune model governed by reaction-diffusion equations ⋮ Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine ⋮ CAR T cell therapy in B-cell acute lymphoblastic leukaemia: insights from mathematical models ⋮ Optimal CAR T-cell immunotherapy strategies for a leukemia treatment model ⋮ Dynamical properties of feedback signalling in B lymphopoiesis: a mathematical modelling approach ⋮ Mathematical models of leukaemia and its treatment: a review

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• Cancer immunotherapy, mathematical modeling and optimal control
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