Transitions between bursting modes in the integrated oscillator model for pancreatic \(\beta\)-cells

DOI10.1016/J.JTBI.2018.06.017zbMath1406.92152OpenAlexW2808759235WikidataQ56976764 ScholiaQ56976764MaRDI QIDQ1714204

Richard Bertram, Isabella Marinelli, Theodore Vo, Luca Gerardo-Giorda

Publication date: 31 January 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://hdl.handle.net/20.500.11824/828

zbMATH Keywords

burstingoscillations

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Physiology (general) (92C30) Cell biology (92C37)

Related Items (5)

Phantom bursting may underlie electrical bursting in single pancreatic \(\beta\)-cells ⋮ Deconstructing the integrated oscillator model for pancreatic \(\beta \)-cells ⋮ Integrated multiscale mathematical modeling of insulin secretion reveals the role of islet network integrity for proper oscillatory glucose-dose response ⋮ Periodic insulin stimulation of Akt: dynamic steady states and robustness ⋮ Fast-slow analysis of the integrated oscillator model for pancreatic \(\beta\)-cells

Cites Work

• A calcium-based phantom bursting model for pancreatic islets
• Mathematical simulation of membrane processes and metabolic fluxes of the pancreatic \(\beta\)-cell
• A phantom bursting mechanism for episodic bursting
• Fast-slow analysis of the integrated oscillator model for pancreatic \(\beta\)-cells
• Calcium and Metabolic Oscillations in Pancreatic Islets: Who's Driving the Bus?

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