Phenotype-centric modeling for elucidation of biological design principles

DOI10.1016/j.jtbi.2018.07.009zbMath1406.92260OpenAlexW2883916546WikidataQ57467574 ScholiaQ57467574MaRDI QIDQ1714317

Rebecca E. Parales, Miguel A. Valderrama-Gómez, Michael A. Savageau

Publication date: 31 January 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.07.009

zbMATH Keywords

system design spacedynamic phenotypesgene circuit architectureglobal robustness and evolvability

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Related Items (1)

Prologue to the special issue of JTB dedicated to the memory of René Thomas (1928--2017). A journey through biological circuits, logical puzzles and complex dynamics

Uses Software

• Design space toolbox

Cites Work

• Recasting nonlinear differential equations as S-systems: a canonical nonlinear form
• Dynamical behaviour of biological regulatory networks. II: Immunity control in bacteriophage lambda
• The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in \textit{Drosophila melanogaster}
• Multistationarity, the basis of cell differentiation and memory. II. Logical analysis of regulatory networks in terms of feedback circuits
• Design principles for elementary gene circuits: Elements, methods, and examples

This page was built for publication: Phenotype-centric modeling for elucidation of biological design principles