Revisiting a skeleton model for the mammalian cell cycle: from bistability to Cdk oscillations and cellular heterogeneity

DOI10.1016/j.jtbi.2018.10.042zbMath1406.92052OpenAlexW2896303078WikidataQ57808574 ScholiaQ57808574MaRDI QIDQ1716919

Albert Goldbeter, Didier Gonze, Claude Gérard

Publication date: 5 February 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/283522/5/Gerard_JTB_2019.pdf

zbMATH Keywords

bistabilityskeleton modelcyclin-dependent kinase oscillationsmammalian cell cycle

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Developmental biology, pattern formation (92C15) Cell biology (92C37) Systems biology, networks (92C42)

Related Items (2)

Prologue to the special issue of JTB dedicated to the memory of René Thomas (1928--2017). A journey through biological circuits, logical puzzles and complex dynamics ⋮ An autonomous mathematical model for the mammalian cell cycle

Cites Work

• Dynamical behaviour of biological regulatory networks. I: Biological role of feedback loops and practical use of the concept of the loop- characteristic state
• Antagonism and bistability in protein interaction networks
• A model for restriction point control of the mammalian cell cycle
• Multistationarity, the basis of cell differentiation and memory. I. Structural conditions of multistationarity and other nontrivial behavior
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