Mathematical modeling of the cGAS pathway reveals robustness of DNA sensing to TREX1 feedback

DOI10.1016/j.jtbi.2018.11.001zbMath1406.92242OpenAlexW2898649863WikidataQ58617233 ScholiaQ58617233MaRDI QIDQ1717278

Jason E. Shoemaker, Saumendra N. Sarkar, Robert W. Gregg

Publication date: 5 February 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2018.11.001

zbMATH Keywords

systems biologyODE modelinginterferon signaling

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Uses Software

• CODA

Cites Work

• Using dynamic sensitivities to characterize metabolic reaction systems
• Weak convergence and optimal scaling of random walk Metropolis algorithms
• Inference from iterative simulation using multiple sequences

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