Mathematical models of DNA methylation dynamics: implications for health and ageing

DOI10.1016/j.jtbi.2018.11.006zbMath1406.92225OpenAlexW2900895453WikidataQ93187067 ScholiaQ93187067MaRDI QIDQ1717286

Mark Mc Auley, Nikos I. Kavallaris, Loukas Zagkos, J. A. Roberts

Publication date: 5 February 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://hdl.handle.net/10034/621555

zbMATH Keywords

sensitivity analysisCpG islandCpG dyadsgene promoter bistabilityhypermethylationhypomethylation

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

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Cites Work

• A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies