Broad cross-reactivity of the T-cell repertoire achieves specific and sufficiently rapid target searching

DOI10.1016/J.JTBI.2019.01.025zbMath1411.92069arXiv1712.04633OpenAlexW2963150450WikidataQ91279338 ScholiaQ91279338MaRDI QIDQ1739293

Jin Xu, Junghyo Jo

Publication date: 26 April 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1712.04633

zbMATH Keywords

molecular recognitiontarget searchingcross-reactivityadaptive immunity

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Physiology (general) (92C30)

Cites Work

• Binding of transcription factors adapts to resolve information-energy tradeoff
• The influence of T cell development on pathogen specificity and autoreactivity
• Random-energy model: An exactly solvable model of disordered systems
• Explaining high alloreactivity as a quantitative consequence of affinity-driven thymocyte selection

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