Hill equation and Hatze's muscle activation dynamics complement each other: enhanced pharmacological and physiological interpretability of modelled activity-pCa curves

DOI10.1016/j.jtbi.2017.07.023zbMath1388.92015OpenAlexW2738914624WikidataQ47746969 ScholiaQ47746969MaRDI QIDQ1746116

Michael Günther, Robert Rockenfeller

Publication date: 24 April 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2017.07.023

zbMATH Keywords

filament overlapcalcium ion concentrationdrug-dose effectforce-pCa curvemuscle excitationsigmoidal curve

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Related Items

A geometry- and muscle-based control architecture for synthesising biological movement, The dynamics of the skeletal muscle: A systems biophysics perspective on muscle modeling with the focus on Hill‐type muscle models, Parameter estimation and experimental design for Hill-type muscles: impulses from optimization-based modeling, Inter-filament spacing mediates calcium binding to troponin: a simple geometric-mechanistic model explains the shift of force-length maxima with muscle activation, A discrete mechanics approach for musculoskeletal simulations with muscle wrapping

Uses Software

• Prism
• GraphPad Prism

Cites Work

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