Spatio-temporal modelling of the NF-\(\kappa\)B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry

DOI10.1016/j.jtbi.2011.08.036zbMath1397.92235OpenAlexW2000035140WikidataQ39708973 ScholiaQ39708973MaRDI QIDQ1786811

Alan J. Terry, Mark A. J. Chaplain

Publication date: 25 September 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2011.08.036

zbMATH Keywords

diffusioncell geometryspatio-temporal modelNF-\(\kappa\)Bactive transport

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Cell biology (92C37)

Related Items (5)

Hopf Bifurcation and Delay-Induced Turing Instability in a Diffusive lac Operon Model ⋮ Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms ⋮ A minimal spatio-temporal model of the NF-\(\kappa \)B signalling pathway exhibits a range of behaviours ⋮ Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling ⋮ A spatial physiological model for p53 intracellular dynamics

Cites Work

• Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
• Mathematical model of NF-\( \kappa\)B regulatory module
• Spatio-Temporal Modelling of the p53–mdm2 Oscillatory System
• Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations
• Oscillation patterns in negative feedback loops

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