Toward an evolutionary containment of evolving pathogen-receptors by using an ensemble of multiple mutant ligands: from the viewpoint of fitness landscape in sequence space

DOI10.1016/J.JTBI.2011.11.030zbMath1397.92308OpenAlexW2050380069WikidataQ45902844 ScholiaQ45902844MaRDI QIDQ1787099

Yuzuru Husimi, Takuyo Aita

Publication date: 26 September 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2011.11.030

zbMATH Keywords

drug-resistanceadaptive ligandescape mutantevolutionary drug-designpeptide-aptamer

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Cites Work

• Chance and necessity in evolution: lessons from RNA
• Toward the fast blind docking of a peptide to a target protein by using a four-body statistical pseudo-potential

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