Optimization of combination therapy for chronic myeloid leukemia with dosing constraints

DOI10.1007/s00285-018-1262-6zbMath1400.49058OpenAlexW2870320297WikidataQ89543368 ScholiaQ89543368MaRDI QIDQ1789085

Lewis Strauss, Helen Moore, Urszula Łedzewicz-Kowalewska

Publication date: 9 October 2018

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-018-1262-6

zbMATH Keywords

optimal controlconstrained optimizationimmunotherapycombination therapychronic myeloid leukemia (CML)tyrosine kinase inhibitors (TKIs)

Mathematics Subject Classification ID

Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15) Cell movement (chemotaxis, etc.) (92C17) Variational principles of physics (49S05)

Related Items (3)

An optimization method for treating solid tumors with combined therapy using the great deluge algorithm ⋮ On the role of the objective in the optimization of compartmental models for biomedical therapies ⋮ On the role of pharmacometrics in mathematical models for cancer treatments

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