Antigen-driven selection in germinal centers as reflected by the shape characteristics of immunoglobulin gene lineage trees: a large-scale simulation study

DOI10.1016/j.jtbi.2008.08.005zbMath1400.92202OpenAlexW2025403752WikidataQ51869406 ScholiaQ51869406MaRDI QIDQ1798191

Malka Gorfine, Neta S. Zuckerman, Michal Barak, Naamah Swerdlin, Ramit Mehr, Gitit Shahaf

Publication date: 23 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2008.08.005

zbMATH Keywords

mathematical modelB lymphocytegerminal center (GC)immunoglobulin (Ig) gene lineage treessomatic hypermutation (SHM)

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37) Genetics and epigenetics (92D10)

Cites Work

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• The type of seeder cells determines the efficiency of germinal center reactions
• Memory in idiotypic networks due to competition between proliferation and differentiation
• A spatial model of germinal center reactions: cellular adhesion based sorting of B cells results in efficient affinity maturation
• A CONCERTED ACTION OF B CELL SELECTION MECHANISMS
• A note on a general definition of the coefficient of determination
• On Randomness in Ordered Sequences
• Measures of Association for Cross Classifications

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