The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation

DOI10.1016/J.JTBI.2008.09.019zbMath1400.92263OpenAlexW2139586726WikidataQ46297704 ScholiaQ46297704MaRDI QIDQ1798658

Anmar Khadra, Leah Edelstein-Keshet, Pere Santamaria

Publication date: 23 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2008.09.019

zbMATH Keywords

modelingdiabetes\(\beta\) cellantigen-presenting cell (APC)T cell avidity

Mathematics Subject Classification ID

Medical applications (general) (92C50) Physiology (general) (92C30)

Related Items (7)

A mathematical model of T1D acceleration and delay by viral infection ⋮ Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes ⋮ The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: a modeling investigation ⋮ Theoretical quantification of the polyvalent binding of nanoparticles coated with peptide-major histocompatibility complex to T cell receptor-nanoclusters ⋮ Modeling immune complex-mediated autoimmune inflammation ⋮ Dependence of CD8 T cell response upon antigen load during primary infection. ⋮ Continuum model of T-cell avidity: understanding autoreactive and regulatory T-cell responses in type 1 diabetes

Cites Work

• Quantifying macrophage defects in type 1 diabetes
• G-CSF control of neutrophils dynamics in the blood
• Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?
• Modeling Cyclic Waves of Circulating T Cells in Autoimmune Diabetes

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