A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data

DOI10.1016/S0025-5564(03)00040-3zbMath1024.92012WikidataQ30788555 ScholiaQ30788555MaRDI QIDQ1810722

Mark P. Little, E. G. Wright

Publication date: 9 June 2003

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

carcinogenesisionizing radiationKolmogorov backward equationscolon cancerKolmogorov forward equationsgenomic instabilitystochastic quasi-mechanistic modelsJapanese atomic bomb survivors

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70)

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Uses Software

• NAG
• nag
• pyuvdata
• bootlib

Cites Work

• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• Are Two Mutations Sufficient to Cause Cancer? Some Generalizations of the Two-Mutation Model of Carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the Multistage Model of Armitage and Doll
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