Equilibrium binding of multivalent ligands to cells: Effects of cell and receptor density

DOI10.1016/0025-5564(96)00022-3zbMath0856.92006OpenAlexW1991278456WikidataQ52301341 ScholiaQ52301341MaRDI QIDQ1817441

Bernhard Sulzer, Alan S. Perelson

Publication date: 24 February 1997

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/0025-5564(96)00022-3

zbMATH Keywords

B cellscell densityligand bindingaviditymultivalent ligandscell surface receptorsequilibrium binding propertieshaptenated polymersimmunon theory of B-cell activationligand depletionligand-induced cell proliferationreceptor concentration

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Physiology (general) (92C30) Asymptotic theory for ordinary differential equations (34E99)

Related Items (2)

A model of cell surface receptor aggregation ⋮ Scaffold-mediated nucleation of protein signaling complexes: elementary principles

Cites Work

• Receptor clustering on a cell surface. I. Theory of receptor cross- linking by ligands bearing two chemically identical functional groups
• Receptor clustering on a cell surface. III. Theory of receptor cross- linking by multivalent ligands: Description by ligand states
• Interpretation of Scatchard plots for aggregating receptor systems
• The kientics of bivalent ligand-bivalent receptor aggregation: Ring formation and the breakdown of the equivalent site approximation
• Unnamed Item

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