Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions

DOI10.1016/S0025-5564(02)00107-4zbMath1024.92010WikidataQ52033519 ScholiaQ52033519MaRDI QIDQ1866974

Iris Burkholder, Annette Kopp-Schneider

Publication date: 2 April 2003

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

multi-stage modelcolor-shift modelhepatocarcinogenesisepigenetic eventspreneoplastic liver lesions

Mathematics Subject Classification ID

Signal detection and filtering (aspects of stochastic processes) (60G35) Medical applications (general) (92C50)

Related Items (2)

Application of a two-phenotype color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment ⋮ Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment

Cites Work

• A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
• A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells
• Are Two Mutations Sufficient to Cause Cancer? Some Generalizations of the Two-Mutation Model of Carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the Multistage Model of Armitage and Doll

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