Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

DOI10.1007/s00285-012-0620-zzbMath1329.92048OpenAlexW2091327029WikidataQ43469976 ScholiaQ43469976MaRDI QIDQ1944637

Lambertus A. Peletier, Neil Benson, Piet H. van der Graaf

Publication date: 26 March 2013

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-012-0620-z

zbMATH Keywords

singular perturbationsystems biologysignal transductionsystems pharmacologyreceptorstyrosine kinase

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Systems biology, networks (92C42)

Related Items (2)

Selecting optimal drug-intervention in a pathway involving receptor tyrosine kinases (RTKs) ⋮ Topics in mathematical pharmacology

Cites Work

• Mathematical analysis of the pharmacokinetic-pharmacodynamic (PKPD) behaviour of monoclonal antibodies: predicting \textit{in vivo} potency
• The Quasi-Steady-State Assumption: A Case Study in Perturbation

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