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On p53 revival using system oriented drug dosage design

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Publication:2013685
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DOI10.1016/j.jtbi.2016.12.008zbMath1368.92052OpenAlexW2566769819WikidataQ48899654 ScholiaQ48899654MaRDI QIDQ2013685

Muhammad Haseeb, Rizwan Azam, Sahar Fazal, Shumaila Azam, Mukhtar Ullah, Aamer Iqbal Bhatti

Publication date: 9 August 2017

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2016.12.008


zbMATH Keywords

cancerp53Mdm2NutlinPBK


Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)


Related Items (3)

Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays ⋮ Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified utkin observer ⋮ Effect of pharmacodynamical interaction between nutlin-3a and aspirin in the activation of p53



Cites Work

  • Oscillations and bistability in the stochastic model of p53 regulation
  • Regulation of p53 by siRNA in radiation treated cells: Simulation studies




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