A mechanistic systems pharmacology modeling platform to investigate the effect of PD-L1 expression heterogeneity and dynamics on the efficacy of PD-1 and PD-L1 blocking antibodies in cancer

DOI10.1016/J.JTBI.2021.110697zbMath1465.92024OpenAlexW3149065451MaRDI QIDQ2029579

Hojjat Bazzazi, Azar Shahraz

Publication date: 3 June 2021

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2021.110697

zbMATH Keywords

tumor heterogeneityreceptor dynamicscancer immunotherapyimmunological synapsecheckpoint inhibitorscytotoxic T cellsnon-tumor immune cellsPD-1PD-L1virtual patients

Mathematics Subject Classification ID

Medical applications (general) (92C50) Pathology, pathophysiology (92C32)

Cites Work

• Nonlinear dynamics of immunogenic tumors: Parameter estimation and global bifurcation analysis
• A mechanistic compartmental model for total antibody uptake in tumors
• A methodology for performing global uncertainty and sensitivity analysis in systems biology

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